Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus

摘要: Status epilepticus (SE) is characterized by continual seizure activity that can vary widely in the intensity of convulsions. We induced seizures applying continuous electrical stimulation to hippocampus adult rats explore effects three different SE states on neurogenesis and neuronal death hippocampus. Rats exhibiting most severe state (fully convulsive) demonstrated profound increases cell proliferation dentate gyrus (DG) at 1 week post-insult, but majority new neurons had died 4 weeks. In contrast, less (ambulatory or masticatory, partial same degree week, survived As compared partially convulsive rats, fully significantly greater DG pathology. Our data indicate varying severity triggers similar short-term neural progenitors, long-term outcome influenced insult-induced degeneration tissue environment.