摘要: Apical–basal cell polarity is crucial for the development of multicellular organisms and diverse functions epithelial cells in organs. Cell characterized by differential distributions protein components apical basolateral membrane domains as well asymmetric intracellular materials. The mainly regulated evolutionary conserved genes, which are Crumbs (Crb) complex Crb, Stardust (Sdt), Pals-1-associated tight junction (Patj), partitioning-defective (Par) Par-3 (Bazooka, Baz), Par-6, atypical kinase C (aPKC). These complexes play fundamental roles initial establishment its maintenance regulation. Recently, these genes their regulations were identified Drosophila retina development. Here, we review recent discoveries Crb Par regulators morphogenesis organogenesis retina.
springer.com
sci-hub.st 参考文章(135)
David Bilder, Norbert Perrimon, Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. ,vol. 403, pp. 676- 680 ,(2000) , 10.1038/35001108
Mark Petronczki, Juergen A. Knoblich, DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nature Cell Biology. ,vol. 3, pp. 43- 49 ,(2001) , 10.1038/35050550
Seungbok Lee, Kerri-Lee Harris, Paul M. Whitington, Peter A. Kolodziej, short stop Is Allelic to kakapo, and Encodes Rod-Like Cytoskeletal-Associated Proteins Required for Axon Extension The Journal of Neuroscience. ,vol. 20, pp. 1096- 1108 ,(2000) , 10.1523/JNEUROSCI.20-03-01096.2000
K J Kemphues, D G Morton, J M Roos, Par-4, a Gene Required for Cytoplasmic Localization and Determination of Specific Cell Types in Caenorhabditis Elegans Embryogenesis Genetics. ,vol. 130, pp. 771- 790 ,(1992) , 10.1093/GENETICS/130.4.771
Bonnie J. Bolkan, Doris Kretzschmar, Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila. Developmental Neurobiology. ,vol. 74, pp. 1210- 1225 ,(2014) , 10.1002/DNEU.22199
K.J. Kemphues, J. Bestman, D.G. Morton, J.L. Watts, The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development. ,vol. 127, pp. 1467- 1475 ,(2000) , 10.1242/DEV.127.7.1467
Fernando Martin-Belmonte, Keith Mostov, Phosphoinositides control epithelial development. Cell Cycle. ,vol. 6, pp. 1957- 1961 ,(2007) , 10.4161/CC.6.16.4583
Hongai Xia, Donald F. Ready, Ectoplasm, ghost in the R cell machine? Developmental Neurobiology. ,vol. 71, pp. 1246- 1257 ,(2011) , 10.1002/DNEU.20898
Ulrich Tepass, Carin Theres, Elisabeth Knust, crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia Cell. ,vol. 61, pp. 787- 799 ,(1990) , 10.1016/0092-8674(90)90189-L
Kenneth Kemphues, PARsing Embryonic Polarity Cell. ,vol. 101, pp. 345- 348 ,(2000) , 10.1016/S0092-8674(00)80844-2