Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis.
作者： E. Hall , P. Hylemon , Z. Vlahcevic , D. Mallonee , K. Valerie
DOI: 10.1152/AJPGI.2001.281.1.G293
关键词:
摘要: In the liver, sterol 27-hydroxylase (CYP27) participates in classic and alternative pathways of bile acid biosynthesis from cholesterol (Chol). extrahepatic tissues, CYP27 converts intracell...
sci-hub.se 参考文章(37)
Gerald Salen, S. Shefer, F. W. Cheng, B. Dayal, A. K. Batta, G. S. Tint, Cholic Acid Biosynthesis Journal of Clinical Investigation. ,vol. 63, pp. 38- 44 ,(1979) , 10.1172/JCI109275
J J Cali, D W Russell, Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. Journal of Biological Chemistry. ,vol. 266, pp. 7774- 7778 ,(1991) , 10.1016/S0021-9258(20)89517-9
W M Kubaska, E C Gurley, P B Hylemon, P S Guzelian, Z R Vlahcevic, Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes. Journal of Biological Chemistry. ,vol. 260, pp. 13459- 13463 ,(1985) , 10.1016/S0021-9258(17)38743-4
W M Pandak, Y C Li, J Y Chiang, E J Studer, E C Gurley, D M Heuman, Z R Vlahcevic, P B Hylemon, Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. Journal of Biological Chemistry. ,vol. 266, pp. 3416- 3421 ,(1991) , 10.1016/S0021-9258(19)67810-5
K E Suckling, E F Stange, Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism. Journal of Lipid Research. ,vol. 26, pp. 647- 671 ,(1985) , 10.1016/S0022-2275(20)34322-4
S. Shefer, S. Hauser, V. Lapar, E.H. Mosbach, HMG CoA reductase of intestinal mucosa and liver of the rat Journal of Lipid Research. ,vol. 13, pp. 402- 412 ,(1972) , 10.1016/S0022-2275(20)39404-9
Isolation, Culture, and Transplantation of Human Hepatocytes Journal of the National Cancer Institute. ,vol. 68, pp. 771- 778 ,(1982) , 10.1093/JNCI/68.5.771
KO Martin, K Budai, NB Javitt, Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes. Journal of Lipid Research. ,vol. 34, pp. 581- 588 ,(1993) , 10.1016/S0022-2275(20)39981-8
K O Martin, A B Reiss, R Lathe, N B Javitt, 7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. Journal of Lipid Research. ,vol. 38, pp. 1053- 1058 ,(1997) , 10.1016/S0022-2275(20)37229-1
Amir Babiker, Ulf Diczfalusy, Transport of side-chain oxidized oxysterols in the human circulation Biochimica et Biophysica Acta. ,vol. 1392, pp. 333- 339 ,(1998) , 10.1016/S0005-2760(98)00047-2