Antimicrobial Susceptibilities of Geographically Diverse Clinical Human Isolates of Leptospira

摘要: Although antimicrobial therapy of leptospirosis has been studied in a few randomized controlled clinical studies, those studies were limited to specific regions the world and have characterized infecting strains. A broth microdilution technique for assessment antibiotic susceptibility developed at Brooke Army Medical Center. In present study, we assessed susceptibilities 13 Leptospira isolates (including recent isolates) from Egypt, Thailand, Nicaragua, Hawaii agents. Ampicillin, cefepime, azithromycin, clarithromycin found MICs below lower limit detection (0.016 μg/ml). Cefotaxime, ceftriaxone, imipenem-cilastatin, penicillin G, moxifloxacin, ciprofloxacin, levofloxacin had MIC90s between 0.030 0.125 μg/ml. Doxycycline tetracycline highest MIC90s: 2 4 μg/ml, respectively. noted slightly higher against Egypt than strains Thailand or Hawaii; otherwise, patterns similar. There appears be possible variability some agents among strains, suggesting that more extensive testing look geographic should pursued.