Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

摘要: Interleukin-6 (IL-6) is a multifunctional cytokine whose circulating levels are under physiological conditions below detection, but production rapidly and strongly induced by several pathological inflammatory stimuli. IL-6 has been implicated in number of cell functions connected to immunity hematopoiesis. Recently, it proposed act as stimulator osteoclast formation activity, particular following estrogen depletion. The purpose this study was gain additional insights into the role during development, well conditions. We report here that deficient mice generated gene targeting viable do not present any evident phenotypic abnormality. However, analysis bone metabolism revealed specific phenotype. female have normal amount trabecular bone, higher rates turnover than control littermates. Estrogen deficiency ovariectomy causes wild type animals significant loss mass together with an increase rates. Strikingly, does induce change either or remodeling mice. These findings indicate plays important local regulation and, at least mice, appears be essential for caused deficiency.