Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis.

摘要: A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) oral loratadine (10 mg/day) in patients with at least two seasons ragweed-induced seasonal allergic rhinitis. 28-day screening period, including a 5-day baseline preceded 4-week treatment period. Reduction rhinitis symptom scores was evident both groups as early day 1, no significant between-group differences during week 1. At weeks 2, 3, 4, treated were significantly (P < 0.05) more improved total nasal score, itch, stuffiness, sneezing than loratadine. 3 rhinorrhea ocular symptoms from among patients. There difference relief postnasal drip any time point. Physicians' global evaluations = 0.002) favored final visit, moderate to complete attained by 68% 59% Over had greater improvement sneezing, symptoms. Both treatments well tolerated, headache being most frequently reported drug-related adverse effect (15%) (11%) groups. These results indicate that is effective relieving