Impaired anti-leukemic immune response in PKCθ-deficient mice

摘要: The cancer immunosurveillance hypothesis has found strong experimental support in recent years. It is believed that cytotoxic lymphocytes are important effectors this process. PKCtheta plays an essential role proliferation, activation and survival of these cells, but also proliferation leukemic T cells. In light this, we tested the cell leukemia progression by inducing disease wild-type (wt) PKCtheta-deficient mice with moloney-murine virus (M-MuLV). Leukemic PKCtheta(-/-) showed same profile types, similar spleen thymus sizes comparable hematocrits. contrast, incidence was higher onset more rapid mice. Transfer cells from wt donors into recipients induced 100% 40% mice, respectively. Interestingly, only 50% 10% recipients. Intravenous injection low numbers EL4 tumors earlier Taken together, our results show for immune response to raise questions about chronic treatment humans inhibitors.