CD44: A Multitude of Isoforms with Diverse Functions
作者： U. Günthert
DOI: 10.1007/978-3-642-78253-4_4
关键词:
摘要: The CD44 transmembrane glycoprotein of 90 kDa has been known for more than 10 years under such diverse designations as lymphocyte homing receptor (gp90Hermes), phagocytic (Pgp-1), extracellular matrix III (ECMRIII) and hyaluronate (H-CAM) (see reviews by Haynes et al. 1989 1991). Studies with monoclonal antibodies revealed similarity, most likely identity, among these molecules (Omary etal. 1988; Gallatin 1989; Picker Aruffo 1990; Miyake Culty 1990). When the human, baboon murine cDNA sequences were established identity was confirmed. However, sequence codes only about 360 amino acids, revealing a 37 protein core (Stamenkovic Goldstein Idzerda Nottenburg Zhou Wolffe This is highly glycosylated N- O-linked sugars to yield 85–90 form sometimes additionally linked chondroitin sulfate side chains produce 180–220 (Jalkanen Stamenkovic 1989).
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