Aspects of positron emission tomography radiochemistry as relevant for food chemistry Review Article

摘要: Summary. Positron emission tomography (PET) is a medical imaging technique using compounds labelled with short-lived positron emitting radioisotopes to obtain functional information of physiological, biochemical and pharmacological processes in vivo. The need understand the potential link between ingestion individual dietary agents effect health promotion or risk requires exact metabolic characterization food ingredients This exciting but rather new research field PET would provide insights perspectives on chemistry by assessing quantitative pharmocokinetics pharmacodynamics agents. To fully exploit technology appropriately radiolabelled as relevant for sciences are needed. most widely used emitters 11 C( t 1=2 ¼ 20.4 min) 18 F( 109.8 min). Longer-lived available 76 Br (t1=2 16.2 h) 124 I( 4.12 d). present review article tries discuss some aspects radiolabelling either means isotopic labelling C via prosthetic group approaches halogens F, I.