Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche
作者： Baukje A Schotanus , Hedwig S Kruitwagen , Ted SGAM van den Ingh , Monique E van Wolferen , Jan Rothuizen
DOI: 10.1186/S12917-014-0309-1
关键词:
摘要: Background The liver has a large regenerative capacity. Hepatocytes can replicate and regenerate diseased liver. However, as is the case in severe diseases, this replication may become insufficient or exhausted hepatic progenitor cells (HPCs) be activated an attempt to restore function. Due their bi-potent differentiation capacity, these HPCs have great potential for approaches yet over-activation does pose health risks. Therefore mechanisms leading activation must elucidated prior safe implementation veterinary clinic. Wnt/β-catenin Notch signalling been implicated of mouse models humans. Here we assessed involvement canine HPC activation. Gene-expression profiles were derived from laser microdissected niches lobular dissecting hepatitis (LDH) normal tissue, with focus on signalling. Immunohistochemical immunofluorescent studies combined assess role pathways during LDH.
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Sarbjit S. Nijjar, Lorraine Wallace, Heather A. Crosby, Stefan G. Hubscher, Alastair J. Strain, Altered Notch Ligand Expression in Human Liver Disease The American Journal of Pathology. ,vol. 160, pp. 1695- 1703 ,(2002) , 10.1016/S0002-9440(10)61116-9
Canals of Hering: recent insights and current knowledge. Seminars in Liver Disease. ,vol. 24, pp. 43- 48 ,(2004) , 10.1055/S-2004-823100
Robert P. Favier, Idiopathic hepatitis and cirrhosis in dogs. Veterinary Clinics of North America-small Animal Practice. ,vol. 39, pp. 481- 488 ,(2009) , 10.1016/J.CVSM.2009.01.002
S Nijjar, Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Hepatology. ,vol. 34, pp. 1184- 1192 ,(2001) , 10.1053/JHEP.2001.29399
Linheng Li, Ian D. Krantz, Yu Deng, Anna Genin, Amy B. Banta, Colin C. Collins, Ming Qi, Barbara J. Trask, Wen Lin Kuo, Joanne Cochran, Teresa Costa, Mary Ella M. Pierpont, Elizabeth B. Rand, David A. Piccoli, Leroy Hood, Nancy B. Spinner, Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 Nature Genetics. ,vol. 16, pp. 243- 251 ,(1997) , 10.1038/NG0797-243
Christoph Köhler, Aaron W. Bell, William C. Bowen, Satdarshan P. Monga, Wolfgang Fleig, George K. Michalopoulos, Expression of Notch-1 and its Ligand Jagged-1 in Rat Liver During Liver Regeneration Hepatology. ,vol. 39, pp. 1056- 1065 ,(2004) , 10.1002/HEP.20156
Andrew W. Duncan, Craig Dorrell, Markus Grompe, Stem Cells and Liver Regeneration Gastroenterology. ,vol. 137, pp. 466- 481 ,(2009) , 10.1053/J.GASTRO.2009.05.044
J. Lim, J. P. Thiery, Epithelial-mesenchymal transitions: insights from development Development. ,vol. 139, pp. 3471- 3486 ,(2012) , 10.1242/DEV.071209
H.S. Kruitwagen, B. Spee, C.S. Viebahn, H.B. Venema, L.C. Penning, G.C.M. Grinwis, R.P. Favier, T.S.G.A.M. van den Ingh, J. Rothuizen, B.A. Schotanus, The canine hepatic progenitor cell niche: Molecular characterisation in health and disease Veterinary Journal. ,vol. 201, pp. 345- 352 ,(2014) , 10.1016/J.TVJL.2014.05.024
Kyoko Ishii, Yoko Yoshida, Yuji Akechi, Tomohiko Sakabe, Ren Nishio, Remina Ikeda, Kei Terabayashi, Yoshiaki Matsumi, Kazue Gonda, Hideharu Okamoto, Kazuko Takubo, Fumihito Tajima, Hiroyuki Tsuchiya, Yoshiko Hoshikawa, Akihiro Kurimasa, Akihiro Umezawa, Goshi Shiota, Hepatic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Tetracycline-Regulated Hepatocyte Nuclear Factor 3β Hepatology. ,vol. 48, pp. 597- 606 ,(2008) , 10.1002/HEP.22362