The Relationship Between Single-Nucleotide Polymorphisms, the Expression of DNA Damage Response Genes, and Hepatocellular Carcinoma in a Polish Population.
作者： Renata Krupa , Piotr Czarny , Paulina Wigner , Joanna Wozny , Maciej Jablkowski
关键词:
摘要: The molecular mechanism of hepatocellular carcinoma (HCC) is related to DNA damage caused by oxidative stress products induced hepatitis B virus (HBV) or C (HCV) infection and exposure environmental pollutants. Single-nucleotide polymorphisms (SNPs) response (DDR) genes may influence individual susceptibility risk factors affect repair efficacy, which, in turn, can the HCC. study evaluates a panel 15 SNPs 11 DDR (XRCC1, XRCC3, XPD, MUTYH, LIG1, LIG3, hOGG1, PARP1, NFIL1, FEN1, APEX1) 65 HCC patients, 50 HBV- HCV-infected non-cancerous healthy controls. It also estimates mRNA expression nine cancerous adjacent liver tissues. Two investigated (rs1052133 rs13181) were associated with risk. For all genes, level was significantly lower cancer tissue than tissue. Seven ...
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