Human papillomavirus and cervical intraepithelial neoplasia grade II-III: a population-based case-control study.
作者： Anne O. Olsen , Kirsti Gjøen , Torill Sauer , Ivar Ørstavik , Oddvar Næss
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摘要: The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there uncertainty about the strength of role co-factors unclear. This population-based case-control study in Norwegian women 20–44 years age included 103 cases with histologically confirmed CIN II–III 234 age-matched randomly selected controls. Cytological specimens from cervix were analyzed using polymerase chain reaction (PCR). In all, 91% 15% controls HPV DNA positive, giving a crude odds ratio (OR) 67.2 (95% confidence interval: 28.6–157.5). 16 was even stronger (crude OR = 123.9; 46.7 - 328.5). logistic regression analysis, additional to HPV, only high number sexual partners low educational level contributed independently risk. adjusted for 72.8 Cl: 27.6–191.9). remains very strong after adjustment proposed confounding factors. results therefore support as causative agent development CIN. © 1995 Wiley-Liss, Inc.
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