The effects of irradiation on controlled drug delivery/controlled drug release systems
作者： Dušan Ražem , Branka Katušin-Ražem
DOI: 10.1016/J.RADPHYSCHEM.2007.06.006
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摘要: Abstract The research of radiation effects on drugs over the past 60 years has mainly dealt with sterilization individual active pharmaceutical ingredients (APIs) in form pure substances or injectable solutions. However, emergence novel systems for drug administration and targeting via controlled delivery (CDD) and/or release (CDR) extended use irradiation respect to pharmaceuticals: capacity act as an initiator crosslinking been used manufacturing modification a number polymeric carriers added advantage reducing microbial load products at same time. application these requires understanding action not only APIs alone but also functioning integral CDD/CDR systems. In this paper, significance is considered special emphasis role developments 15 years. Radiation sterilization, degradation principal forms carrier kinetics are discussed light chemical principles. Regulatory aspects pertaining considered. Relevant results summarized tabular form.
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