Herpesvirus hominis infection in newborn mice. I. An experimental model and therapy with iododeoxyuridine.

摘要: Although treatment of disseminated Herpesvirus hominis (HVH) infections the newborn human infant has resulted in both success and failure, there have been no controlled studies to evaluate effect therapy on either outcome or pathogenesis disease. Infection mouse with genital type 2 strain HVH by intranasal route provides an experimental model disease man. After inoculation a mouse, virus multiplies lung is through blood liver spleen, brain viremia nerve-route transmission. Therapy iododeoxyuridine (IUDR) did not affect mortality, although significant was observed. Viral replication reduced, viremia, as well subsequent involvement completely eliminated. In contrast, transmission central nervous system (CNS) affected therapy. Lack inhibition viral CNS appeared be due inadequate levels IUDR tissue likely explanation for therapeutic failure this infection. These observations suggest possible reasons variable results reported herpesvirus infants.