Regulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle.
作者： Danielle M. Trappanese , Sarah Sivilich , Hillevi K. Ets , Farah Kako , Michael V. Autieri
DOI: 10.1152/AJPCELL.00311.2015
关键词:
摘要: Vascular smooth muscle contraction is primarily regulated by phosphorylation of myosin light chain. There are also modulatory pathways that control the final level force development. We tested hypothesis protein kinase C (PKC) and mitogen-activated (MAP) modulate vascular activity via effects on MAP phosphatase-1 (MKP-1). Swine carotid arteries were mounted for isometric recording subjected to histamine stimulation in presence absence inhibitors PKC [bisindolylmaleimide-1 (Bis)], (MEK) (U0126), MKP-1 (sanguinarine) flash frozen measurement kinase, PKC-potentiated phosphatase inhibitor 17 (CPI-17), caldesmon levels. CPI-17 was phosphorylated response inhibited Bis. Caldesmon levels increased decreased MEK inhibition but not affected addition Inhibition significantly p42 p44 kinase. with U0126 both activity. sanguinarine blocked Bis-dependent increase Sanguinarine alone due its MKP-1. phosphorylation, which This suggests has a negative feedback role inhibiting Therefore, catalyzes reversed Thus fine tuning concerted effort PKC,
sci-hub.se 参考文章(63)
T J Childs, A S Mak, Smooth-muscle mitogen-activated protein (MAP) kinase: purification and characterization, and the phosphorylation of caldesmon Biochemical Journal. ,vol. 296, pp. 745- 751 ,(1993) , 10.1042/BJ2960745
J L Duff, M B Marrero, W G Paxton, C H Charles, L F Lau, K E Bernstein, B C Berk, Angiotensin II induces 3CH134, a protein-tyrosine phosphatase, in vascular smooth muscle cells. Journal of Biological Chemistry. ,vol. 268, pp. 26037- 26040 ,(1993) , 10.1016/S0021-9258(19)74271-9
Jennifer L. Duff, Brett P. Monia, Bradford C. Berk, Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells Journal of Biological Chemistry. ,vol. 270, pp. 7161- 7166 ,(1995) , 10.1074/JBC.270.13.7161
T.J. Childs, M.H. Watson, J.S. Sanghera, D.L. Campbell, S.L. Pelech, A.S. Mak, Phosphorylation of smooth muscle caldesmon by mitogen-activated protein (MAP) kinase and expression of MAP kinase in differentiated smooth muscle cells. Journal of Biological Chemistry. ,vol. 267, pp. 22853- 22859 ,(1992) , 10.1016/S0021-9258(18)50025-9
W. G. Wier, K. G. Morgan, α1-Adrenergic signaling mechanisms in contraction of resistance arteries Reviews of Physiology Biochemistry and Pharmacology. ,vol. 150, pp. 91- 139 ,(2003) , 10.1007/S10254-003-0019-8
Bhupal P. Bhetwal, Kenton M. Sanders, Changlong An, Danielle M. Trappanese, Robert S. Moreland, Brian A. Perrino, Ca2+sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus The Journal of Physiology. ,vol. 591, pp. 2971- 2986 ,(2013) , 10.1113/JPHYSIOL.2013.255745
Annabel F. Valledor, Jordi Xaus, Mònica Comalada, Concepció Soler, Antonio Celada, Protein kinase C epsilon is required for the induction of mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. Journal of Immunology. ,vol. 164, pp. 29- 37 ,(2000) , 10.4049/JIMMUNOL.164.1.29
Mitul N. Bavaria, Shi Jin, Ramesh M. Ray, Leonard R. Johnson, The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis Apoptosis. ,vol. 19, pp. 467- 479 ,(2014) , 10.1007/S10495-013-0944-1
Arnold S. Baas, Bradford C. Berk, Differential Activation of Mitogen-Activated Protein Kinases by H2O2 and O2− in Vascular Smooth Muscle Cells Circulation Research. ,vol. 77, pp. 29- 36 ,(1995) , 10.1161/01.RES.77.1.29
Philipp Stawowy, Stephan Goetze, Christian Margeta, Eckart Fleck, Kristof Graf, LPS regulate ERK1/2-dependent signaling in cardiac fibroblasts via PKC-mediated MKP-1 induction Biochemical and Biophysical Research Communications. ,vol. 303, pp. 74- 80 ,(2003) , 10.1016/S0006-291X(03)00301-2