G1 Phase Cyclins in Cancer Development and Progression

摘要: Cyclin D1 and cyclin E are rate limiting for progression through G1 entry into S phase during the cell cycle. plays a crucial role in linking favorable environmental conditions with cycle progression. indirectly induces expression activation, which is required phase. The deregulated of either would thus greatly impact on cell’s ability to effectively regulate It perhaps not surprising therefore, that both play important roles development cancer. This chapter explores these cyclins For clarity, major focus will be well-characterized lesser extent other such as D2 D3. summarizes evidence cancer cellular pathways underlie well their oncogenic also discussed. Lastly, potential serve therapeutic targets therapy explored.