The location of coenzyme Q10 in phospholipid membranes made of POPE: a small-angle synchrotron X-ray diffraction study
作者： Christoph Wollstein , Mathias Winterhalter , Sérgio S. Funari
DOI: 10.1007/S00249-015-1031-Z
关键词:
摘要: The location of coenzyme Q10 (Q10) inside the inner mitochondrial membrane is a topic research aiming at deeper understanding function respiratory chain. We investigated Q10 model membranes made 1-palmitoyl-2-oleoyl-phosphatidylethanolamine by means small-angle synchrotron X-ray diffraction. Q10, which stands for ubiquinone-10 (UQ) or ubihydroquinone-10 (UH), did not remarkably influence main phase transition temperature, but significantly decreased lamellar-inverse hexagonal temperature (T h). effect UH on T h was stronger than UQ and liquid crystalline Q10. In presence lattice parameters lamellar phases remained unchanged, whereas H II lattice parameter clearly influenced: While had an increasing effect, decreasing effect. Furthermore, prevented formation cubic phases. results give new evidence that headgroup distant from center membrane, might be important
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Małgorzata Jemiota-Rzemińska, Dariusz Latowski, Kazimierz Strzałka, Incorporation of plastoquinone and ubiquinone into liposome membranes studied by HPLC analysis. The effect of side chain length and redox state of quinone. Chemistry and Physics of Lipids. ,vol. 110, pp. 85- 94 ,(2001) , 10.1016/S0009-3084(00)00227-9
Haralambos KATSIKAS, Peter J. QUINN, The Distribution of Ubiquinone‐10 in Phospholipid Bilayers FEBS Journal. ,vol. 124, pp. 165- 169 ,(1982) , 10.1111/J.1432-1033.1982.TB05920.X
Jose CASTRESANA, Alicia ALONSO, Jose-Luis R. ARRONDO, Felix M. GONI, Hector CASAL, The physical state of ubiquinone-10, in pure form and incorporated into phospholipid bilayers. A Fourier-transform infrared spectroscopic study. FEBS Journal. ,vol. 204, pp. 1125- 1130 ,(1992) , 10.1111/J.1432-1033.1992.TB16737.X
Juan C. Gómez-Fernández, Maria A. Llamas, Francisco J. Aranda, The interaction of coenzyme Q with phosphatidylethanolamine membranes. FEBS Journal. ,vol. 259, pp. 739- 746 ,(2001) , 10.1046/J.1432-1327.1999.00109.X
Justas Barauskas, Valdemaras Razumas, Tommy Nylander, Solubilization of ubiquinone-10 in the lamellar and bicontinuous cubic phases of aqueous monoolein. Chemistry and Physics of Lipids. ,vol. 97, pp. 167- 179 ,(1999) , 10.1016/S0009-3084(98)00107-8
C. Hunte, V. Zickermann, U. Brandt, Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I Science. ,vol. 329, pp. 448- 451 ,(2010) , 10.1126/SCIENCE.1191046
Michael Rappolt, Andrea Hickel, Frank Bringezu, Karl Lohner, Mechanism of the Lamellar/Inverse Hexagonal Phase Transition Examined by High Resolution X-Ray Diffraction Biophysical Journal. ,vol. 84, pp. 3111- 3122 ,(2003) , 10.1016/S0006-3495(03)70036-8
Gregor Cevc, How membrane chain-melting phase-transition temperature is affected by the lipid chain asymmetry and degree of unsaturation: an effective chain-length model. Biochemistry. ,vol. 30, pp. 7186- 7193 ,(1991) , 10.1021/BI00243A021
Satoshi Endo, Beate I. Escher, Kai-Uwe Goss, Capacities of Membrane Lipids to Accumulate Neutral Organic Chemicals Environmental Science & Technology. ,vol. 45, pp. 5912- 5921 ,(2011) , 10.1021/ES200855W
Andrea Hickel, Sabine Danner-Pongratz, Heinz Amenitsch, Gabor Degovics, Michael Rappolt, Karl Lohner, Georg Pabst, Influence of antimicrobial peptides on the formation of nonlamellar lipid mesophases. Biochimica et Biophysica Acta. ,vol. 1778, pp. 2325- 2333 ,(2008) , 10.1016/J.BBAMEM.2008.05.014