Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives
作者： Jong-Hwan Jeon , Yoshiki Chujo , Kazuo Tanaka , Masahiro Murakami
DOI: 10.1039/C1OB06630G
关键词:
摘要: We report that a polyhedral oligomeric silsesquioxane (POSS) core in dendrimer can enhance the affinity of molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation naphthyridine ligands with series nucleotides was investigated, it is shown POSS should play significant role stabilization complexes bonds. Finally, we demonstrate ligand selectively recognize triphosphate by assisting POSS-core dendrimer.
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