Occupation, occupational exposures and mammographic density in Spanish women.

摘要: Abstract Introduction Mammographic density (MD), the proportion of radiologically dense breast tissue, is a strong risk factor for cancer. Our objective to investigate influence occupations and occupational exposure physical, chemical, microbiological agents on MD in Spanish premenopausal women. Methods This cross-sectional study based 1362 workers, aged 39–50, who attended gynecological screening radiodiagnosis unit Madrid City Council. The work history was compiled through personal interview. Exposure evaluated using job-exposure matrix MatEmESp. percentage assessed validated semi-automated computer tool DM-Scan. association between occupation, exposures, quantified multiple linear regression models, adjusted age, educational level, body mass index, parity, previous biopsies, family cancer, energy intake, use oral contraceptives, smoking, alcohol consumption. Results Although no occupation statistically significantly associated with MD, borderline significant inverse mainly observed orchard, greenhouse, nursery, garden workers (β = −6.60; 95% confidence interval (95%CI) = -14.27; 1.07) information communication technology technicians (β = −7.27; 95%CI = −15.37; 0.84). On contrary, positive found among art galleries, museums, libraries (β = 8.47; 95%CI = −0.65; 17.60). Women occupationally exposed fungicides, herbicides, insecticides tended have lower MD. decreased by almost 2% every 5 years spent mentioned agents. Conclusions our findings point lack exposures analyzed, this supports deeper exploration role certain such as pesticides.