Method for evaluating and applying an individual's genetic characteristics to determine response to cardiovascular medication therapy

作者: John F. Carlquist , Robert R. Pearson , Joseph B. Muhlestein , Benjamin D. Horne

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摘要: A process for evaluating the genetic sensitivity of individual patients to medications and appropriately prescribing or not medication according established correlations between specific is described. In present preferred embodiment/example, this invention provides a determining whether person, having either cardiovascular disease risk factors, has characteristic which would indicate ordinarily prescribed statin likely be effective even detrimental.

参考文章(3)
Huiying Yang, Kent D. Taylor, Jerome I. Rotter, Maren T. Scheuner, Genetic test to determine non-responsiveness to statin drug treatment ,(2000)
Jan Albert Kuivenhoven, J. Wouter Jukema, Aeilko H. Zwinderman, Peter de Knijff, Ruth McPherson, Albert V.G. Bruschke, Kong I. Lie, John J.P. Kastelein, The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis New England Journal of Medicine. ,vol. 338, pp. 86- 93 ,(1998) , 10.1056/NEJM199801083380203