Visible-Light-Promoted Radical C–H Trifluoromethylation of Free Anilines
作者： Jin Xie , Xiangai Yuan , Ablimit Abdukader , Chengjian Zhu , Jing Ma
DOI: 10.1021/OL500469A
关键词:
摘要: The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free with commercially available easily handled Togni reagent at room temperature. resulting products were successfully transformed into a variety valuable fluorine-containing molecules heterocyclic compounds. This protocol provides an economical powerful route to trifluoromethylated anilines.
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