Childhood-Onset Schizophrenia: The Severity of Premorbid Course

摘要: ABSTRACT Objective To review the premorbid histories of 23 children meeting DSM-III-R criteria for schizophrenia with onset before age 12 years and to compare these childhood data later-onset schizophrenics. Method Premorbid features up 1 year first psychotic symptoms were rated from hospital clinic records, clinical interviews, rating scales, tests. Results In keeping previous studies, specific developmental disabilities transient early autism, particularly motor stereotypies, common. Comparison schizophrenics showed greater delay in language development, more speech disorders, learning disruptive behavior disorders. (Sixty percent had received or estimated meet one diagnoses.) Conclusions Childhood-onset may represent a malignant form disorder, although selection ascertainment bias cannot be ruled out. The presence prepsychotic difficulties focuses attention on importance temporal frontal lobe development; stereotypies suggest basal ganglia abnormalities extend findings seen patients.