Antibodies against human il 17 and uses thereof
作者： Hendrik Knoetgen , Guy Georges , Petra Hanke , Claire Louise Langrish , Nikolaos Dimoudis
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摘要: An antibody binding to IL- 17 characterized by the same epitope which monoclonal 3C1 binds, and being of human IgG1 isotype modified in hinge region at amino acid position 216-240, preferably 220-240, between C H 1 2 and/or second inter-domain 327-331 3 has advantageous properties for treatment inflammatory diseases.
google.sh参考文章(1)
Jean-Michel Rene Rondeau, Hermann Gram, Margit Jeschke, Franco E. Di Padova, Hans Hofstetter, Wim Van Den Berg, IL-17 antagonistic antibodies ,(2005)