The combination of block copolymers and phospholipids to form giant hybrid unilamellar vesicles (GHUVs) does not systematically lead to "intermediate" membrane properties.

摘要: In this work, the elasticity under stretching as well fluidity of Giant Hybrid Unilamellar Vesicles (GHUV) has been studied. The membrane structuration these GHUVs already studied at micro and nanoscale in a previous study team. These were obtained by association fluid phospholipid (POPC) triblock copolymer, poly(ethyleneoxide)-b-poly(dimethylsiloxane)-b-poly(ethyleneoxide). Although architecture copolymers can facilitate vesicle formation, they have scarcely used to generate GHUVs. We show, through micropipette aspiration FRAP experiments, that incorporation low amount lipids polymer leads significant loss toughness subtle modification lateral diffusion chains. discuss results within framework conformation copolymer chain presence lipid nanodomains.