Altered plasma levels of cytokines, soluble adhesion molecules and matrix metalloproteases in venous thrombosis

摘要: Abstract Background/aim Recent studies have emphasized the importance of inflammatory response mediated by monocyte and neutrophil activation in deep venous thrombosis (DVT); we therefore investigated whether this was reflected plasma profile mediators patients with suspected DVT. Methods We included a group 169 consecutive admitted to hospital from primary health care service lower limb Plasma levels 43 were examined for cohort 89 20 healthy controls Luminex multiplex analyses, i.e. 13 interleukins, 3 immunomodulatory cytokines, 8 chemokines, growth factors, adhesion molecules matrix metalloproteases. Selected analyzed second 80 patients. Results Thirty-five (21%) referred diagnosed Only P-selectin (p  Conclusion biomarker profiling selected soluble can be used identify subsets among that differ significantly their frequencies