TGF-β-Elicited Induction of Tissue Inhibitor of Metalloproteinases (TIMP)-3 Expression in Fibroblasts Involves Complex Interplay between Smad3, p38α, and ERK1/2

作者: Suvi-Katri Leivonen , Konstantinos Lazaridis , Julie Decock , Andrew Chantry , Dylan R. Edwards

DOI: 10.1371/JOURNAL.PONE.0057474

关键词:

摘要: … signaling in TGF-β-elicited TIMP-3 gene expression, we analyzed TIMP-3 … h TGF-β stimulation of empty control virus (RAdpCA3) infected fibroblasts resulted in marked induction of TIMP-…

参考文章(55)
V.-M. Kähäri, J. Uitto, Yue Qiu Chen, P. Carrillo, R. W. Rhudy, D. R. Olsen, Transforming growth factor-beta up-regulates elastin gene expression in human skin fibroblasts. Evidence for post-transcriptional modulation. Laboratory Investigation. ,vol. 66, pp. 580- 588 ,(1992)
K.J. Leco, R. Khokha, N. Pavloff, S.P. Hawkes, D.R. Edwards, Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. Journal of Biological Chemistry. ,vol. 269, pp. 9352- 9360 ,(1994) , 10.1016/S0021-9258(17)37115-6
David A. YOUNG, Blaine W. PHILLIPS, Caroline LUNDY, Robert K. NUTTALL, Aileen HOGAN, Gilbert A. SCHULTZ, Kevin J. LECO, Ian M. CLARK, Dylan R. EDWARDS, Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene. Biochemical Journal. ,vol. 364, pp. 89- 99 ,(2002) , 10.1042/BJ3640089
Mikko J. Rönty, Suvi-Katri Leivonen, Boris Hinz, Andrew Rachlin, Carol A. Otey, Veli-Matti Kähäri, Olli M. Carpén, Isoform-Specific Regulation of the Actin-Organizing Protein Palladin during TGF-β1-Induced Myofibroblast Differentiation Journal of Investigative Dermatology. ,vol. 126, pp. 2387- 2396 ,(2006) , 10.1038/SJ.JID.5700427
Peter ten Dijke, Caroline S Hill, New insights into TGF-β–Smad signalling Trends in Biochemical Sciences. ,vol. 29, pp. 265- 273 ,(2004) , 10.1016/J.TIBS.2004.03.008
Pekka T. Heikkinen, Marika Nummela, Suvi-Katri Leivonen, Jukka Westermarck, Caroline S. Hill, Veli-Matti Kähäri, Panu M. Jaakkola, Hypoxia activated Smad3-specific dephosphorylation by PP2A Journal of Biological Chemistry. ,vol. 285, pp. 3740- 3749 ,(2010) , 10.1074/JBC.M109.042978
Alicia R. Folgueras, Alberto M. Pendas, Luis M. Sanchez, Carlos Lopez-Otin, Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. The International Journal of Developmental Biology. ,vol. 48, pp. 411- 424 ,(2004) , 10.1387/IJDB.041811AF
S-K Leivonen, R Ala-aho, K Koli, R Grénman, J Peltonen, V-M Kähäri, Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells. Oncogene. ,vol. 25, pp. 2588- 2600 ,(2006) , 10.1038/SJ.ONC.1209291
Mikala Egeblad, Zena Werb, New functions for the matrix metalloproteinases in cancer progression Nature Reviews Cancer. ,vol. 2, pp. 161- 174 ,(2002) , 10.1038/NRC745