Cognitive deficits in Parkinson’s disease

摘要: Neuropsychological investigations of patients with Parkinson's disease have shown specific impairments even in the early stages disease, which include deficit behavioural regulation sorting or planning tasks, defective use memory stores, and impaired manipulation internal representation visuospatial stimuli. These deficits, reported a predominantly involves subcortical structures, drawn attention to potential role basal ganglia cognitive processes. Given modulatory ganglia, these disorders might result from more fundamental deficits concerning allocation attentional resources, temporal organization behaviour, maintenance representations working self-elaboration strategies, all resemble dysfunctions processes that are commonly considered be controlled by frontal lobes. This suggests functional continuity complementarity between association areas prefrontal cortex. The recent description primates segregated loops interconnect discrete regions caudate nucleus dorsolateral orbitofrontal cortex via thalamus may give some support this hypothesis. Alternatively, degeneration ascending cholinergic catecholaminergic neuronal systems contribute, at least part, occurrence frontal-lobe-like symptomatology associated disease.