Evaluation of two chlorhexidine-alcohol-based skin disinfectants in blood donation setting.

摘要: Background Source reduction is important in minimizing bacterial-contaminated risk of blood products, but previous evaluation chlorhexidine (CHX) was confounded by inability Tween and lecithin to neutralize CHX. The study aims address this limitation also evaluates the effectiveness two CHX–alcohol-based skin disinfectants donation setting. Methods A two-stage observational conducted. A single step 2% gluconate/70% isopropyl alcohol brush (CHX/IPA-1) first compared with current disinfection procedure consisting sequential application 10% povidone-iodine 70% (PI/IPA). Standard plates conventional neutralizers (0·3% Tween-80, 0·1% lecithin) were used enumerate residual bacterial counts. Then, CHX/IPA-1 another applicator CHX/IPA-2 identical disinfectant contents using in-house (3% 0·3% lecithin, histidine, 0·5% sodium thiosulphate, 3% saponin, 1% ether sulphate) having enhanced ability CHX. Results All three products found reduce plate counts > 2 log10 after disinfection. group gave fewer growth on standard than PI/IPA (5·9% vs. 61·7%, P < 0·001). With use plates, no difference both groups (42·5% 49·4%, P = 0·26). Conclusion Good efficacy observed one-stage CHX/IPA predonation it could replace PI/IPA. However, be grossly overestimated testing because insufficient neutralization.