Clinical implications of benign multiple sclerosis: A 20-year population-based follow-up study

作者: Sean J. Pittock , Robyn L. McClelland , William T. Mayr , Neal W. Jorgensen , Brian G. Weinshenker

DOI: 10.1002/ANA.20197

关键词:

摘要: In 2001, we followed up all patients from the 1991 Olmsted County Multiple Sclerosis (MS) prevalence cohort. We found that longer duration of MS and lower disability, more likely a patient is to remain stable not progress. This particularly powerful for with benign Expanded Disability Status Scale score 2 or 10 years who have greater than 90% chance remaining stable. important because these represent 17% entire These data should assist in shared therapeutic decision-making process whether start immunomodulatory medications.

参考文章(20)
John F. Kurtzke, Gilbert W. Beebe, Benedict Nagler, Leonard T. Kurland, Thomas L. Auth, Studies on the natural history of multiple sclerosis—8 Journal of Chronic Diseases. ,vol. 30, pp. 819- 830 ,(1977) , 10.1016/0021-9681(77)90010-8
H. J. Bauer, W. Firnhaber, W. Winkler, PROGNOSTIC CRITERIA IN MULTIPLE SCLEROSIS Annals of the New York Academy of Sciences. ,vol. 122, pp. 542- 551 ,(2006) , 10.1111/J.1749-6632.1965.TB20234.X
O. Vuia, THE BENIGN FORM OF MULTIPLE SCLEROSIS Acta Neurologica Scandinavica. ,vol. 55, pp. 289- 298 ,(1977) , 10.1111/J.1600-0404.1977.TB05648.X
Jens O.L. Jørgensen, Morten Krag, Niels Jessen, Helene Nørrelund, Esben T. Vestergaard, Niels Møller, Jens S. Christiansen, Growth Hormone and Glucose Homeostasis Hormone Research in Paediatrics. ,vol. 62, pp. 51- 55 ,(2004) , 10.1159/000080499
S A Hawkins, G V McDonnell, Benign multiple sclerosis? Clinical course, long term follow up, and assessment of prognostic factors Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 67, pp. 148- 152 ,(1999) , 10.1136/JNNP.67.2.148
M. Rodriguez, A. Siva, J. Ward, K. Stolp-Smith, P. O'Brien, L. Kurland, Impairment, disability, and handicap in multiple sclerosis: A population-based study in Olmsted County, Minnesota Neurology. ,vol. 44, pp. 28- 28 ,(1994) , 10.1212/WNL.44.1.28
B. G. WEINSHENKER, G. P. A. RICE, J. H. NOSEWORTHY, W. CARRIERE, J. BASKERVILLE, G. C. EBERS, The natural history of multiple sclerosis: a geographically based study. 3. Multivariate analysis of predictive factors and models of outcome. Brain. ,vol. 114, pp. 1045- 1056 ,(1991) , 10.1093/BRAIN/114.2.1045
S. J. Pittock, W. T. Mayr, R. L. McClelland, N. W. Jorgensen, S. D. Weigand, J. H. Noseworthy, B. G. Weinshenker, M. Rodriguez, Change in MS-related disability in a population-based cohort A 10-year follow-up study Neurology. ,vol. 62, pp. 51- 59 ,(2004) , 10.1212/01.WNL.0000101724.93433.00