Differential pattern of deposition of nanoparticles in the airways of exposed workers.

摘要: Ultrafine particles (UFP) have been postulated to significantly contribute the adverse health effects associated with exposure particulate matter (PM). Due their extremely small size (aerodynamic diameter <100 nm), UFP are able deposit deep within lung after inhalation and evade many mechanisms responsible for clearance of larger particles. There is a lack biologically relevant personal metrics occupational- environmental-related micro- nano-sized PM. The aim present study assess in induced sputum (IS) exhaled breath condensate (EBC) as possible biomarkers assessing function impairment. Sputum induction EBC testing were performed by conventional methods. assessed NanoSight LM20 (NanoSight Ltd, London, UK). subjects included 35 exposed 25 non-exposed workers. no group differences pulmonary test results differential cell counts, but 63.6% had higher percentage neutrophils (OR3.28 p = 0.03) compared subjects. percentages between 10 50 nm (69.45 ± 18.70 vs 60.11 17.52 group, 0.004). No found IS samples. Years correlated positively content (r 0.342 0.01) macrophage −0.327 0.03). fraction EBC, not IS, workers, may be sensitive biomarker nanoparticles.