Targeting Bruton's tyrosine kinase in B cell malignancies
作者： Rudi W. Hendriks , Saravanan Yuvaraj , Laurens P. Kil
DOI: 10.1038/NRC3702
关键词:
摘要: Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and functions as an important regulator proliferation survival in various malignancies. Small-molecule inhibitors BTK have shown antitumour activity animal models and, recently, clinical studies. High response rates were reported patients with chronic lymphocytic leukaemia mantle lymphoma. Remarkably, molecular effects that cannot be explained by the classic role BCR signalling. In this Review, we highlight importance pathways context its therapeutic inhibition.
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