Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen.

摘要: Peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipocyte differentiation, has recently been connected with effector T cells, though its role is still not clear. Here, we investigated the roles PPARγ in follicular helper (TFH) cell responses regarding gender specificity. NP-OVA immunization female but male CD4-PPARγKO mice induced higher proportions TFH cells and germinal center (GC) B following than were seen wild type mice. Treatment agonist pioglitazone significantly reduced while estradiol (E2) co-treatment ameliorated GC E2 treatment enhanced expression activation estrus diestrus stage menstrual cycle females was inhibited by pioglitazone, suggesting that an estrogen-sufficient environment important for PPARγ-mediated regulation. These results demonstrate gender-based differences sensitivities responses. findings suggest appropriate function required regulation therapeutic strategies autoimmune diseases using agonists need to be tailored accordingly.