QTc interval measurement and metabolic parameters in psychiatric patients taking typical or atypical antipsychotic drugs: a preliminary study.

摘要: Background Antipsychotic drugs have been associated with prolongation of the QTc interval on electrocardiogram, and is, in turn, an increased risk cardiac arrhythmias sudden death. polypharmacy has implicated reduced survival, possibly secondary to cardiotoxic effects antipsychotic medication. Abnormalities glucose homeostasis, which may be more common individuals major mood disorders schizophrenia, also affect interval. Method We performed detailed assessment metabolic parameters 103 psychiatric out-patients, from across diagnostic spectrum, who had taking medication (typical, atypical, or a combination thereof) for minimum 6 months. measured subset these patients (N = 65). Results Only 2 (3%) prolonged There was statistical trend (p .08) toward lower receiving polypharmacy. age .04) but not any parameter. Conclusion this population is uncommon. significant association between increasing interval, repolarization related Further large prospective studies similar are needed confirm findings.