Long-term results of autologous bone marrow transplantation in adult acute lymphoblastic leukemia

摘要: Autologous bone marrow transplantation (BMT) is widely performed in both adult and high-risk pediatric acute lymphoblastic leukemia (ALL). Nevertheless, there still a lack of definitive data concerning its real effectiveness prolonging the survival these patients. Between 1984 1992, 20 ALL patients first, second third complete remission (CR) underwent autografting BMT Unit University Milan. This series included 3 children CR after one or more hematological relapses while all other were adult. was harvested during same disease phase as that which autologous performed. The conditioning regimen high-dose Ara-C, cyclophosphamide TBI 1000 cGy. Successful engraftment occurred patients; no early deaths recorded, making disease-free event-free (EFS) curves superimposable. overall chance EFS at 72 months 41%: 57% for first CR, 53% p...