The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet
作者： James S. McTaggart , Rebecca H. Clark , Frances M. Ashcroft
DOI: 10.1113/JPHYSIOL.2010.191767
关键词:
摘要: ATP-sensitive potassium (KATP) channels are critical for the maintenance of glucose homeostasis. They essential glucose-stimulated insulin secretion from pancreatic β-cells, contribute to mechanisms by which hypoglycaemia stimulates glucagon release α-cells, and involved in uptake into skeletal muscle, production liver, feeding behaviour. Not surprisingly, loss- or gain-of-function mutations KATP channel genes have profound effects, giving rise congenital hyperinsulinaemia neonatal diabetes respectively. This symposium review focuses on our current understanding role homeostasis health disease.
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