Estimates of probability of transmitter release at the mammalian neuromuscular junction

摘要: 1. Intracellular records of end-plate potentials (e.p.p.s) were obtained from curarized neuromuscular junctions in the rat diaphragm.2. Statistical estimates quantal release probability (p) made at individual measurements means and variances e.p.p. amplitudes two different levels Ca concentration. It was assumed that process binomial number quanta available for (n) independent external Ca.3. These p compared with those by measuring depression after single conditioning shocks assuming due to depletion n. The statistical consistently smaller.4. This disparity, plus additional observation not linearly related released one or more shocks, suggested entirely assumption led an over-estimate p.5. A third method estimating decline during rapid stimulation also appeared result over-estimate.