Nebulized Lidocaine in the Treatment of Intractable Cough

作者: Kelly Truesdale , Adham Jurdi

DOI: 10.1177/1049909112458577

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摘要: Cough is one of the most common symptoms prompting patients to be seen by health care providers in United States. Persistent cough can disrupt daily activities such as conversation, eating, breathing, and sleeping, it become extremely debilitating both physically mentally. Pharmacological treatments include dextramethorphan, opioid suppressants, benzonatate, inhaled ipratropium, guaifenesin. Successful suppression has also been demonstrated several studies with use nebulized lidocaine. Nebulized lidocaine appears well tolerated minimal side effects including dysphonia, oropharyngeal numbness, bitter taste. Studies conducted thus far have small, so larger randomized control trials comparing placebo need future.

参考文章(20)
Craig W Swainey, Patrick J Coyne, Thomas J Smith, Brian M Lingerfelt, Nebulized lidocaine for intractable cough near the end of life. The journal of supportive oncology. ,vol. 5, pp. 301- 302 ,(2007)
Bassam Estfan, Susan LeGrand, Management of cough in advanced cancer. The journal of supportive oncology. ,vol. 2, pp. 523- 527 ,(2004)
Sherman Jm, Breaking the cycle: lidocaine therapy for habit cough The Journal of the Florida Medical Association. ,vol. 84, pp. 308- 309 ,(1997)
Alex Molassiotis, Chris Bailey, Ann Caress, Jing-Yu Tan, Interventions for cough in cancer Cochrane Database of Systematic Reviews. ,vol. 5, pp. 1- 58 ,(2015) , 10.1002/14651858.CD007881.PUB3
Lorne A Becker, Jeffrey Hom, Miguel Villasis-Keever, Johannes C van der Wouden, Beta2-agonists for acute bronchitis Cochrane Database of Systematic Reviews. ,vol. 18, ,(2011) , 10.1002/14651858.CD001726.PUB4
Susan M Smith, Knut Schroeder, Tom Fahey, Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database of Systematic Reviews. ,vol. 2014, pp. 001831- ,(2014) , 10.1002/14651858.CD001831.PUB5
Scott Trochtenberg, Nebulized Lidocaine in the Treatment of Refractory Cough Chest. ,vol. 105, pp. 1592- 1593 ,(1994) , 10.1378/CHEST.105.5.1592
Peter V. Dicpinigaitis, Yvonne E. Gayle, Gail Solomon, Richard D. Gilbert, Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough Respiratory Medicine. ,vol. 103, pp. 902- 906 ,(2009) , 10.1016/J.RMED.2008.12.008
Peter V. Dicpinigaitis, Leah Spinner, Ganesha Santhyadka, Abdissa Negassa, Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough Lung. ,vol. 186, pp. 369- 374 ,(2008) , 10.1007/S00408-008-9114-6
C J Stewart, T J Coady, Suppression of intractable cough. BMJ. ,vol. 1, pp. 1660- 1661 ,(1977) , 10.1136/BMJ.1.6077.1660-D