Testosterone Metabolism and Action in Testicular Feminization Syndrome

摘要: Publisher Summary This chapter discusses testosterone metabolism and action in testicular feminization syndrome. The syndrome of (TF) is an intriguing abnormality human sex differentiation. inherited has been described several species addition to humans, including the cow, dog, rat, mouse. In most cases, common feature that, despite a normal rate production, these genetically male subjects have external genitalia breast characteristics phenotypic females, absence internal other than testis, striking resistance endogenous exogenous androgens. It assumed that lack masculinization caused by defect during fetal life puberty. cytoplasmic system binding dihydrotestosterone possibly dependent on secretion because vitro it decreases very rapidly after castration. different steps involved androgen activity at cellular level are each other; particular, initial presence active within cell seems be necessary. also describes 5α-reduction