A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress.

摘要: Escherichia coli treated with nontoxic levels of the superoxide-generating redox-cycling agents menadione and paraquat showed dramatic changes in protein composition as monitored by two-dimensional gel analysis. The distribution proteins synthesized after treatment these overlapped significantly that seen hydrogen peroxide treatment, it included all oxyR regulon. also elicited synthesis at least 33 other were not peroxide, including three heat shock proteins, Mn-containing superoxide dismutase, DNA repair endonuclease IV, glucose-6-phosphate dehydrogenase. At some redox-inducible appear to be part a specific response intracellular superoxide. E. is thus equipped network inducible responses against oxidative damage, controlled multiple regulatory pathways.