The current stage of cathepsin B inhibitors as potential anticancer agents

摘要: Cathepsin B is a lysosomal cysteine peptidase, with an important role in the development and progression of cancer. It involved degradation extracellular matrix proteins, process promoting invasion metastasis tumor cells angiogenesis. unique among cathepsins possessing both carboxypeptidase endopeptidase activities. While former associated its physiological role, latter pathological matrix. Its activities are regulated by different means, most being endogenous inhibitors, cystatins. In cancer this peptidase/inhibitor balance altered, leading to harmful cathepsin activity. The can be prevented exogenous inhibitors. They differ modes inhibition, size, structure, binding affinity, selectivity, toxicity bioavailability. article, we review properties function inhibitors indicate their appl...