Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.

摘要: Tetracyclines are potent inhibitors of 2 major matrix metalloproteinases which have been implicated in connective tissue degradation: collagenase and Type IV collagenase/gelatinase. We directly identified these enzyme activities extracts inflamed paw from rats with adjuvant arthritis. Oral tetracycline therapy suppressed metalloproteinase activity arthritic tissue, but even very high doses failed to exhibit substantial antiinflammatory efficacy (reduced joint swelling diameter). Flurbiprofen, a conventional nonsteroidal drug, reduced inflammatory indices as expected. The combination the agents administered orally completely inhibited activity, significantly gelatinase produced normalization radiographic damage, far greater than either drug alone. Tetracycline inhibition curves vitro suggest that this is not fibroblast origin. derivatives might be useful adjuncts prevention damage chronic arthritides.