CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

Johnny Stiban, Rotem Tidhar, Anthony H. Futerman, Ceramide synthases: roles in cell physiology and signaling. Advances in Experimental Medicine and Biology. ,vol. 688, pp. 60- 71 ,(2010) , 10.1007/978-1-4419-6741-1_4

Svati H. Shah, William E. Kraus, Christopher B. Newgard, Metabolomic Profiling for the Identification of Novel Biomarkers and Mechanisms Related to Common Cardiovascular Diseases Form and Function Circulation. ,vol. 126, pp. 1110- 1120 ,(2012) , 10.1161/CIRCULATIONAHA.111.060368

Philipp Ebel, Katharina vom Dorp, Elisabeth Petrasch-Parwez, Armin Zlomuzica, Kiyoka Kinugawa, Jean Mariani, David Minich, Christina Ginkel, Jochen Welcker, Joachim Degen, Matthias Eckhardt, Ekrem Dere, Peter Dörmann, Klaus Willecke, Inactivation of Ceramide Synthase 6 in Mice Results in an Altered Sphingolipid Metabolism and Behavioral Abnormalities Journal of Biological Chemistry. ,vol. 288, pp. 21433- 21447 ,(2013) , 10.1074/JBC.M113.479907

Yael Pewzner-Jung, Ori Brenner, Svantje Braun, Elad L. Laviad, Shifra Ben-Dor, Ester Feldmesser, Shirley Horn-Saban, Daniela Amann-Zalcenstein, Calanit Raanan, Tamara Berkutzki, Racheli Erez-Roman, Oshrit Ben-David, Michal Levy, Dorin Holzman, Hyejung Park, Abraham Nyska, Alfred H. Merrill, Anthony H. Futerman, A Critical Role for Ceramide Synthase 2 in Liver Homeostasis II. INSIGHTS INTO MOLECULAR CHANGES LEADING TO HEPATOPATHY Journal of Biological Chemistry. ,vol. 285, pp. 10911- 10923 ,(2010) , 10.1074/JBC.M109.077610

Lihong Zhao, Stefka D. Spassieva, Thomas J. Jucius, Leonard D. Shultz, H. Elizabeth Shick, Wendy B. Macklin, Yusuf A. Hannun, Lina M. Obeid, Susan L. Ackerman, A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation PLoS Genetics. ,vol. 7, pp. e1002063- ,(2011) , 10.1371/JOURNAL.PGEN.1002063

Benjamin T. Bikman, Scott A. Summers, Ceramides as modulators of cellular and whole-body metabolism Journal of Clinical Investigation. ,vol. 121, pp. 4222- 4230 ,(2011) , 10.1172/JCI57144

Christina Ginkel, Dieter Hartmann, Katharina vom Dorp, Armin Zlomuzica, Hany Farwanah, Matthias Eckhardt, Roger Sandhoff, Joachim Degen, Mariona Rabionet, Ekrem Dere, Peter Dörmann, Konrad Sandhoff, Klaus Willecke, Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes Journal of Biological Chemistry. ,vol. 287, pp. 41888- 41902 ,(2012) , 10.1074/JBC.M112.413500

V. Menuz, K. S. Howell, S. Gentina, S. Epstein, I. Riezman, M. Fornallaz-Mulhauser, M. O. Hengartner, M. Gomez, H. Riezman, J.-C. Martinou, Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science. ,vol. 324, pp. 381- 384 ,(2009) , 10.1126/SCIENCE.1168532

Timothy R Koves, John R Ussher, Robert C Noland, Dorothy Slentz, Merrie Mosedale, Olga Ilkayeva, James Bain, Robert Stevens, Jason RB Dyck, Christopher B Newgard, Gary D Lopaschuk, Deborah M Muoio, None, Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance Cell Metabolism. ,vol. 7, pp. 45- 56 ,(2008) , 10.1016/J.CMET.2007.10.013

Joo-Won Park, Woo-Jae Park, Yael Kuperman, Sigalit Boura-Halfon, Yael Pewzner-Jung, Anthony H. Futerman, Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent‐resistant membranes Hepatology. ,vol. 57, pp. 525- 532 ,(2013) , 10.1002/HEP.26015