Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential α-glucosidase inhibitors.
作者： Mahmood Biglar , Bagher Larijani , Haleh Hamedifar , Mir Hamed Hajimiri , Nafise Asemanipoor
DOI: 10.1016/J.BIOORG.2019.103482
关键词:
摘要: In this study, a series of benzimidazole-1,2,3-triazole hybrids 8a-n as new α-glucosidase inhibitors were designed and synthesized. In vitro α-glucosidase inhibition activity results …
sci-hub.se 参考文章(16)
Françoise Payan, Structural basis for the inhibition of mammalian and insect α-amylases by plant protein inhibitors Biochimica et Biophysica Acta. ,vol. 1696, pp. 171- 180 ,(2004) , 10.1016/J.BBAPAP.2003.10.012
Alain D Baron, Postprandial hyperglycaemia and α-glucosidase inhibitors Diabetes Research and Clinical Practice. ,vol. 40, ,(1998) , 10.1016/S0168-8227(98)00043-6
Ebenezer A. Nyenwe, Terri W. Jerkins, Guillermo E. Umpierrez, Abbas E. Kitabchi, Management of Type 2 Diabetes: Evolving Strategies for the Treatment of Patients With Type 2 Diabetes Metabolism-clinical and Experimental. ,vol. 60, pp. 1- 23 ,(2011) , 10.1016/J.METABOL.2010.09.010
Yan-Gan Chen, Ping Li, Peng Li, Ru Yan, Xiao-Qi Zhang, Ying Wang, Xian-Tao Zhang, Wen-Cai Ye, Qing-Wen Zhang, α-Glucosidase inhibitory effect and simultaneous quantification of three major flavonoid glycosides in Microctis folium. Molecules. ,vol. 18, pp. 4221- 4232 ,(2013) , 10.3390/MOLECULES18044221
K. Barry Sharpless, M. G. Finn, Hartmuth C. Kolb, Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angewandte Chemie. ,vol. 40, pp. 2004- 2021 ,(2001) , 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.3.CO;2-X
P. Hollander, Safety Profile of Acarbose, an α-Glucosidase Inhibitor Drugs. ,vol. 44, pp. 47- 53 ,(1992) , 10.2165/00003495-199200443-00007
Farukh Jabeen, Syeda Aaliya Shehzadi, Muhammad Qaiser Fatmi, Sobia Shaheen, Lubna Iqbal, Nighat Afza, Siva S. Panda, Farzana Latif Ansari, Synthesis, in vitro and computational studies of 1,4-disubstituted 1,2,3-triazoles as potential α-glucosidase inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 26, pp. 1029- 1038 ,(2016) , 10.1016/J.BMCL.2015.12.033
Leila Dinparast, Hassan Valizadeh, Mir Babak Bahadori, Somaieh Soltani, Behvar Asghari, Mohammad-Reza Rashidi, Design, synthesis, α-glucosidase inhibitory activity, molecular docking and QSAR studies of benzimidazole derivatives Journal of Molecular Structure. ,vol. 1114, pp. 84- 94 ,(2016) , 10.1016/J.MOLSTRUC.2016.02.005
Musa Özil, Mustafa Emirik, Semiha Yılmaz Etlik, Serdar Ülker, Bahittin Kahveci, A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies. Bioorganic Chemistry. ,vol. 68, pp. 226- 235 ,(2016) , 10.1016/J.BIOORG.2016.08.011
Guangcheng Wang, Zhiyun Peng, Jing Wang, Juan Li, Xin Li, Synthesis and biological evaluation of novel 2,4,5-triarylimidazole-1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters. ,vol. 26, pp. 5719- 5723 ,(2016) , 10.1016/J.BMCL.2016.10.057