Targeting Cellular Cofactors in HIV Therapy

摘要: Besides viral proteins cellular factors play a key role in the replication of human immunodeficiency virus HIV-1. The outcome is determined by balance between activity number dependency and restriction factors. Whereas first are essential cofactors for diverse steps cycle, latter counteract sensing particular components as non-self, often mediators innate immune system. Cellular include receptors HIV-1 entry, LEDGF cofactor integrase, RNA helicase DDX3 involved nuclear export unspliced RNAs, kinases that promote replication. antagonized accessory order to their restrictive function on Although HIV field understood promoting replication, we add subchapter most important (Trim5α, APOBEC3G, SAMHD1, tetherin/BST-2). Today highly active antiretroviral therapy (HAART) mostly targets like reverse transcriptase, protease, or integrase specifically interfere with However, identification increasing knowledge mode action at defined cycle have opened new avenues towards development inhibitors. Here summarize along therapeutic approaches developed target them, preferentially without harming normal function.