In vivo effect of zinc on iron-induced ferritin synthesis in rat liver

摘要: Abstract The effect of excess (0.75%) dietary zinc on the induction rat liver ferritin synthesis by intraperitoneal injection iron was studied in vivo . Ferritin isolated a chromatographic method from livers control-fed and 0.75% zinc-fed rats which had been given with trace level 59 Fe, followed at various time intervals to 23 h 2-h pulse dose [ 14 C]leucine. labeled precursors were used study toxicity formation micelle protein moiety response administration. Iron resulted an increase total iron, Fe activity, both groups rats. However, ratio iron: approximately one-third that controls. This remained essentially constant throughout period Thus, results “iron-poor ferritin”. Zinc does not appear interfere incorporation C]amino acids into ferritin, indicating zinc-fec can synthesize de novo Evidence is obtained suggests turnover rate may be faster than seem associated purified rats, although partially fractions these do contain large amounts zinc.