The Diabetic Zucker Fatty Rat

摘要: A noninsulin-dependent diabetes appeared in fatty rats our Zucker rat colony. breeding program yielded a genetic pattern of consistent with dominant gene not closely linked to the gene. Fatty males were more frequently affected than females. Since no markers could be identified for heterozygous carriers and since 6 months old when appeared, diabetic trait sustained small Glucose tolerance tests showed that had little increase plasma insulin concentration after glucose load was administered. Plasma concentrations unchanged relative control rats. Percentage body fat triglyceride values decreased rats, however, resistance liver. The content pancreatic markedly either ad libitum or diet-restricted occurrence genetically based normally outbred colony underscores importance traits interact obesity determining rodent models.