Mouse skin tumorigenicity studies of indoor coal and wood combustion emissions from homes of residents in Xuan Wei, China with high lung cancer mortality

摘要: The rural Xuan Wei County, Yunnan Province, China, has an unusually high lung cancer mortality rate that cannot be attributed to tobacco smoke or occupational exposure. is associated with 'smoky' coal, in contrast wood 'smokeless' coal burned unventilated homes. This study was conducted characterize and compare mouse skin tumorigenicity of the combustion emissions link animal data human cancer. Indoor air particles (less than 10 microns) were collected from a central commune where smoky major fuel used also south-western low smokeless are fuels used. organic extracts these indoor analysed for polycyclic aromatic hydrocarbons assayed tumor initiation activity complete carcinogenicity SENCAR mice. results showed extract emission most active among three samples followed by then wood. shown potent carcinogen, whereas relatively inactive as carcinogen. not tested because inadequate supply. Eighty-eight percent mice treated carcinomas, averaging 1.1 carcinomas per tumor-bearing at end 77 week study. These findings agreement epidemiological data, which residents using homes had rate. demonstrates assays data.