Dose-Adjusted EPOCH-Rituximab Therapy in Primary Mediastinal B-Cell Lymphoma

摘要: BackgroundPrimary mediastinal B-cell lymphoma is a distinct subtype of diffuse large-B-cell that closely related to nodular sclerosing Hodgkin's lymphoma. Patients are usually young and present with large masses. There no standard treatment, but the inadequacy immunochemotherapy alone has resulted in routine consolidation radiotherapy, which potentially serious late effects. We aimed develop strategy improves rate cure obviates need for radiotherapy. MethodsWe conducted single-group, phase 2, prospective study infusional dose-adjusted etoposide, doxorubicin, cyclophosphamide vincristine, prednisone, rituximab (DA-EPOCH-R) filgrastim without radiotherapy 51 patients untreated primary used results from retrospective DA-EPOCH-R another center independently verify outcomes. ResultsThe had median age 30 years (range, 19 52) media...