Quantification of the spectrum of changes in regional myocardial function during acute ischemia in closed chest pigs: an ultrasonic strain rate and strain study.

摘要: The objectives of this study were to define the spectrum regional myocardial function changes during acute ischemia in closed chest animals by using newly developed ultrasonic strain rate and indexes derived from color Doppler imaging (CDMI) velocity data. Myocardial was induced 18 pigs either with total 20-second occlusions (group 1, n = 12) or graded hypoperfusion (40 0 mL/min, group 2, 6) circumflex coronary artery. In addition, a dobutamine challenge (5 10 microg/kg per minute) performed sustained subtotal (10 mL/min) 2. CDMI acquisitions parasternal views monitored posterior wall function. Regional radial (epsilon(r)) measured for systole, isovolumic relaxation, early diastole, atrial filling, respectively. During ischemia, epsilon(r) profiles consistently modified, showing delayed onset decrease systolic thickening as well increased postsystolic thickening. Radial decreased systole diastole relaxation. End-systolic could differentiate severe mL/min), decreasing 32% +/- 8% 16% 5% (versus 60% 10% at baseline). infusion minute), end-systolic tended 27% 18% 11%, whereas 2-fold (P <.05). combined analysis deformation characteristics global cardiac event timing data can identify quantify experimental pigs. This would appear be potentially promising new noninvasive approach clinical evaluation ischemia-induced segmental