Regulation of immunity to Plasmodium: implications from mouse models for blood stage malaria vaccine design.
DOI: 10.1016/J.EXPPARA.2010.01.028
关键词:
摘要: Malaria, a disease caused by the protozoan parasite Plasmodium, remains serious healthcare problem in developing countries worldwide. While host-parasite relationship humans has been difficult to determine, pliability of murine malaria models enabled valuable contributions understanding pathogenesis disease. Although no single model reflects precisely infection human, different collectively provide important information on mechanisms protective immunity and immunopathogenesis. This review summarizes progress towards broad spectrum immune responsiveness blood stages during experimental infections mice highlights how examination malarias sheds light factors involved modulation vaccine-potentiated immunity.
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